Evolutionary BiologybioRxivPreprint
A stepwise model for asp gene emergence across HIV and SIV lineages: progressive stop-codon loss and regulatory evolution
DOI 10.64898/2026.09.03.749113
Author
Akio Kanai
Keio UniversityORCID 0000-0002-6362-2419Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2026 · peak 3/yrCo-Author Collaboration Network
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Curved chords = mutual co-authorship7 papers
Recent·Most cited
- MicrobiologybioRxivPreprint
Identification of Novel Gamma Radiation-Responsive Genes in the Thiosulfate-Oxidizing Bacterium Limnobacter thiooxidans
Tomoro Warashina, Asako Sato, Yuma Dotsuta…·Akio Kanai
This study identifies three novel gamma radiation-responsive genes in Limnobacter thiooxidans and shows that overexpression of LT3126 significantly increases survival after high-dose irradiation.
DOI 10.64898/2026.05.23.727404 - Molecular BiologyNucleic Acids ResearchPeer-reviewed
SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents
Yuki Iimori, Teppei Morita, Takeshi Masuda…·Akio Kanai
This study shows SLFN11 induces cell death by cleaving tRNALeu(TAA), causing ER stress and disrupting proteostasis in response to DNA-damaging agents.
7 citations - Evolutionary BiologyJournal of Molecular EvolutionPeer-reviewed
Possible acquisition and molecular evolution of vpu genes inferred from comprehensive sequence analysis of human and simian immunodeficiency viruses
Miu Naruki, Motofumi Saito, Masako Nomaguchi, Akio Kanai
This study analyzes Vpu gene sequences from HIV and SIV to classify them into four types and infer their evolutionary origins and divergence.
- Molecular BiologybioRxivPreprint
Proteome-level robustness and the role of a histone-like protein during acute heat shock in the hyperthermophilic archaeon Pyrococcus furiosus
Haruko Okabe, Masahiro C. Miura, Asako Sato…·Akio Kanai
This study examines the transcriptomic and proteomic responses of Pyrococcus furiosus to acute heat shock, revealing proteome stability, translation suppression, and a potential role for a histone-like protein in chromatin formation.
DOI 10.1101/2025.05.02.651969 - Molecular BiologyJournal of BacteriologyPeer-reviewed
Comprehensive analysis of insertion sequences within rRNA genes of CPR bacteria and biochemical characterization of a homing endonuclease encoded by these sequences
Megumi Tsurumaki, Asako Sato, Motofumi Saito, Akio Kanai
The paper analyzes insertion sequences in CPR bacteria's rRNA genes and characterizes homing endonucleases encoded by these sequences, showing their prevalence and unique structural features.
7 citations - BioinformaticsRNAPeer-reviewed
Features of smaller ribosomes in Candidate Phyla Radiation (CPR) bacteria revealed with a molecular evolutionary analysis
Megumi Tsurumaki, Motofumi Saito, Masaru Tomita, Akio Kanai
The paper analyzes genomic data from CPR bacteria to show they have smaller ribosomes with simplified surface structures due to missing proteins and rRNA regions.
19 citations