SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents
Yuki Iimori, Teppei Morita, Takeshi Masuda, Shojiro Kitajima, Nobuaki Kono, Shun Kageyama, Josephine Galipon, Atsuo T. Sasaki, Akio Kanai
This study shows SLFN11 induces cell death by cleaving tRNALeu(TAA), causing ER stress and disrupting proteostasis in response to DNA-damaging agents.
Nucleic Acids Research · Aug 1, 2025Peer-reviewedMolecular Biology