Leah L. Weber

Arborist improves tumor phylogeny reconstruction by integrating bulk DNA-seq and low-pass scDNA-seq data, outperforming existing methods on simulated and biological datasets.

This paper introduces a method to jointly reconstruct the evolutionary history of SNVs and CNAs from low-coverage single-cell DNA sequencing data, demonstrating improved accuracy over single-modality approaches.

This paper introduces a method to infer clonal trees from ultra-low coverage single-cell DNA sequencing data of tumors, showing improved accuracy in uncovering clonal structure and genotypes.

PhyDOSE optimizes follow-up single-cell sequencing experiments using bulk data to reduce costs while maintaining accurate tumor phylogeny reconstruction.