Author

Gopinath Chattopadhyay

SIB Swiss Institute of BioinformaticsORCID 0000-0002-6408-1968Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Andreas WagneriD· 2 shared Andrei PapkouiD· 1 shared Cauã Antunes WestmanniD· 1 shared Diego PesceiD· 1 shared Pouria DasmehiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersEvolutionary Biology

Andreas WagnerORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintJul 3, 2026

Negative Autoregulation Promotes the Evolution of Strong Environmental Switching

Pouria Dasmeh, Gopinath Chattopadhyay, Diego Pesce…·Andreas Wagner

This study shows that negative autoregulation in gene circuits enables stronger environmental switching by favoring alleles that create strong molecular switches in E. coli.

DOI 10.64898/2026.06.30.735141

E. coliDNA methylation

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintJul 23, 2025

The fitness landscape of the E.coli lac operator is highly rugged in two different environments

Gopinath Chattopadhyay, Andrei Papkou, Andreas Wagner

The paper maps the fitness landscape of E. coli lac operator variants in two environments, finding highly rugged landscapes with few shared fitness peaks.

2 citations

E. coligenetic perturbation / CRISPR

𝕏 PostBluesky