Cauã Antunes Westmann

The paper examines how the regulatory scope of bacterial transcription factors influences the adaptive landscapes of their binding sites, finding systematic differences in mutational robustness, peak distribution, and evolvability.

This study maps in vivo adaptive landscapes for three Escherichia coli transcription factors, revealing rugged landscapes with pervasive epistasis and showing de novo gene regulation is feasible but constrained.

This study shows that negative autoregulation in gene circuits enables stronger environmental switching by favoring alleles that create strong molecular switches in E. coli.

This study shows that bacterial transcription factor binding sites can evolve exaptively through small adaptive mutations, leading to regulatory crosstalk and new gene regulation functions.

This paper develops a modular probiotic system in Escherichia coli Nissle1917 that detects nitric oxide and secretes anti-TNF nanobodies to mitigate gut inflammation.

The paper constructs synthetic promoters in E. coli to study how cis-regulatory element arrangements affect transcription factor binding and gene expression outcomes.

The paper identifies false positives in metagenomic screenings using lacZα-based vectors due to small DNA insertions within the lacZα gene, highlighting the need to report screening boundaries.