Eva Cuypers

Thyra converts Mass Spectrometry Imaging data into the SpatialData format to improve interoperability and enable multi-modal spatial analysis.

This study integrates spatial transcriptomics and MALDI-MSI to reveal spatial lipid-gene coupling in glioblastoma, showing distinct metabolic niches in tumor-core and invasive regions.

The paper identifies iron deposition as a distinct phase of intraplaque hemorrhage, associated with inflammation and remodeling, through transcriptomic, histological, and metabolic analyses of human atherosclerotic plaques.

This paper integrates MALDI-MSI and spatial transcriptomics on the same tissue section to achieve precise spatial alignment and uncover metabolic and transcriptomic heterogeneity.