Atherosclerotic plaque iron accumulation characterizes a distinct phase of intra-plaque hemorrhage and is associated with inflammation and remodeling
Elias B Wieland, Aniek Plug, Benjamin Balluff, Marion J. Gijbels, Lele Han, Bryn Flinders, Eva Cuypers, Laura Kempen, Xiaofei Li, Barend Mees, Erik A.L. Biessen, Marjo M. P. C. Donners, Pieter Goossens
The paper identifies iron deposition as a distinct phase of intraplaque hemorrhage, associated with inflammation and remodeling, through transcriptomic, histological, and metabolic analyses of human atherosclerotic plaques.
bioRxiv · Apr 30, 2026 · PreprintPathology