Author

Klaus Dieter McDonald-Maier

University of EssexORCID 0000-0002-6412-8519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:batch correction / integration· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Leonard C. SchalkwykiD· 3 shared Olivia A. GrantiD· 3 shared Xiaojun ZhaiiD· 3 shared Yucheng WangiD· 3 shared T.J. Gorrie-StoneiD· 2 shared Alexandria AndrayasiD· 1 shared Eilis J. HannoniD· 1 shared Jonathan S. MilliD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 33 mutual co-author links

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3 shared papersBioinformatics

Leonard C. SchalkwykORCID

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3 papers

Recent·Most cited

interpolatedXY: a two-step strategy to normalise DNA methylation microarray data avoiding sex bias

Yucheng Wang, T.J. Gorrie-Stone, Olivia A. Grant, Alexandria Andrayas, Xiaojun Zhai, Klaus Dieter McDonald-Maier, Leonard C. Schalkwyk

The paper introduces a two-step normalization strategy for DNA methylation microarray data to reduce sex bias by separately normalizing autosomal and sex chromosome CpGs.

Bioinformatics · Jun 30, 2022Peer-reviewedBioinformatics

Recalibrating the cerebellum DNA methylation clock: implications for ageing rates comparison

Yucheng Wang, Olivia A. Grant, Xiaojun Zhai, Klaus Dieter McDonald-Maier, Leonard C. Schalkwyk

The paper develops a cerebellum-specific DNA methylation clock and finds it outperforms existing clocks, revealing the cerebellum ages more slowly than other brain tissues.

bioRxiv · May 16, 2022 · PreprintBioinformatics

DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

Yucheng Wang, Eilis J. Hannon, Olivia A. Grant, T.J. Gorrie-Stone, Meena Kumari B, Jonathan S. Mill, Xiaojun Zhai, Klaus Dieter McDonald-Maier, Leonard C. Schalkwyk

The paper presents a DNA methylation-based sex classifier that predicts sex and identifies sex chromosome aneuploidy using CpG sites from whole blood samples.

BMC Genomics · Jun 28, 2021Peer-reviewedBioinformatics