Yucheng Wang

The paper introduces a two-step normalization strategy for DNA methylation microarray data to reduce sex bias by separately normalizing autosomal and sex chromosome CpGs.

The paper develops a cerebellum-specific DNA methylation clock and finds it outperforms existing clocks, revealing the cerebellum ages more slowly than other brain tissues.

The paper identifies sex-associated differentially methylated CpG sites and regions in whole blood using the Illumina EPIC array, revealing their genomic locations and enrichment for sex-related transcription factors.

The paper presents a DNA methylation-based sex classifier that predicts sex and identifies sex chromosome aneuploidy using CpG sites from whole blood samples.