Olivia A. Grant

Explainable AI identifies H3K18ac as a new marker of active enhancers

The paper develops AI models to predict enhancers in human and mouse cell lines, identifying H3K18ac as a new enhancer marker and annotating enhancers using a combination of epigenetic marks.

Systematic investigation of interindividual variation of DNA methylation in human whole blood

The paper identifies stable and variable DNA methylation loci in human whole blood using the IlluminaEPIC array, showing their genomic distribution and genetic control.

Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis

The paper identifies sex-associated DNA methylation differences in ALS using a large-scale epigenome-wide association study and links them to survival outcomes.

H4K16ac activates transcription of transposable elements and contribute to their cis regulatory function

The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.

interpolatedXY: a two-step strategy to normalise DNA methylation microarray data avoiding sex bias

The paper introduces a two-step normalization strategy for DNA methylation microarray data to reduce sex bias by separately normalizing autosomal and sex chromosome CpGs.

Recalibrating the cerebellum DNA methylation clock: implications for ageing rates comparison

The paper develops a cerebellum-specific DNA methylation clock and finds it outperforms existing clocks, revealing the cerebellum ages more slowly than other brain tissues.

Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array

The paper identifies sex-associated differentially methylated CpG sites and regions in whole blood using the Illumina EPIC array, revealing their genomic locations and enrichment for sex-related transcription factors.

Locus-specific chromatin profiling of evolutionarily young transposable elements

The paper develops a method to generate locus-specific chromatin profiles at transposable elements using HiChIP and PAtChER, revealing epigenetic variation in young TEs in mouse and human cells.

DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

The paper presents a DNA methylation-based sex classifier that predicts sex and identifies sex chromosome aneuploidy using CpG sites from whole blood samples.