Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
Mathieu Bourdenx, Aurélien Nioche, Sandra Doveró, Marie-Laure Arotçarena, Sandrine M. J. Camus, Grégory Porras, Marie-Laure Thiolat, Nicolas P. Rougier, Annick Prigent, Philippe Aubert, Sylvain Bohic, Christophe Sandt, Florent Laferrière, Évelyne Doudnikoff, Niels Kruse, , Erwan Bézard
The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.
Science Advances · May 13, 2020Peer-reviewedNeuroscience