Author

Marie-Laure Arotçarena

Centre National de la Recherche ScientifiqueORCID 0000-0002-1306-3700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Erwan BézardiD· 2 shared Florent LaferrièreiD· 2 shared Amanda J. LewisiD· 1 shared Annick PrigentiD· 1 shared Antoine LoquetiD· 1 shared Ariadna RecasensiD· 1 shared Aude RetailleauiD· 1 shared Aurélien NiocheiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Erwan BézardORCID

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2 papers

Recent·Most cited

Synthetic alpha-synuclein fibrils replicate in mice causing MSA-like pathology

Domenic Burger, Marianna Kashyrina, Lukas van den Heuvel, Hortense de La Seiglière, Amanda J. Lewis, Francesco De Nuccio, Inayathulla Mohammed, Jérémy Verchère, Cécile Feuillie, Mélanie Berbon, Marie-Laure Arotçarena, Aude Retailleau, Erwan Bézard, Marie‐Hélène Canron, Wassilios G. Meissner, , François Ichas

This study shows synthetic alpha-synuclein fibrils can replicate in mice, causing MSA-like pathology and forming glial cytoplasmic inclusions.

Nature · Nov 5, 2025Peer-reviewedNeuroscience

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates

Mathieu Bourdenx, Aurélien Nioche, Sandra Doveró, Marie-Laure Arotçarena, Sandrine M. J. Camus, Grégory Porras, Marie-Laure Thiolat, Nicolas P. Rougier, Annick Prigent, Philippe Aubert, Sylvain Bohic, Christophe Sandt, Florent Laferrière, Évelyne Doudnikoff, Niels Kruse, , Erwan Bézard

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.

Science Advances · May 13, 2020Peer-reviewedNeuroscience