Author

Giuseppe Orlando

Atrium Health Wake Forest BaptistORCID 0000-0002-6460-7974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Amish AsthanaiD· 2 shared Benjamin D. HumphreysiD· 1 shared Gabriel C. OniscuiD· 1 shared Hao WuiD· 1 shared Melanie WalkeriD· 1 shared Michael R. LevittiD· 1 shared Nicolas LedruiD· 1 shared Parker C. WilsoniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Amish AsthanaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Dose Modeling for Mitochondrial Transplantation in Barrier-Limited Tissues

Melanie Walker, Giuseppe Orlando, Amish Asthana, Gabriel C. Oniscu, Michael R. Levitt

The paper develops a computational model to estimate mitochondrial transplantation doses for barrier-limited tissues, finding route-adjusted requirements differ from cardiac estimates.

bioRxiv · Jul 8, 2025 · PreprintPharmacology & Toxicology

Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing

Nicolas Ledru, Parker C. Wilson, Yoshiharu Muto, Yasuhiro Yoshimura, Hao Wu, Amish Asthana, Stefan G. Tullius, Sushrut S. Waikar, Giuseppe Orlando, Benjamin D. Humphreys

The paper develops RENIN, a regularized regression method, to predict gene regulatory networks from single nucleus multiomic data and applies it to identify regulators of failed kidney injury response.

bioRxiv · Dec 29, 2022 · PreprintGenomics