Nicolas Ledru

Multi-omics profiling of mouse polycystic kidney disease progression at a single cell resolution

This study uses single-nucleus multi-omics to analyze mouse PKD progression, identifying cell-type-specific gene and epigenetic changes and conserved regulatory pathways between mouse and human.

Epigenetic reprogramming driving successful and failed repair in acute kidney injury

This study maps epigenetic changes during AKI repair in mice and humans, identifying CREB5 as a regulator of both successful and failed tubular repair.

Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing

The paper develops RENIN, a regularized regression method, to predict gene regulatory networks from single nucleus multiomic data and applies it to identify regulators of failed kidney injury response.

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

This study uses single-cell multiomic analysis to define cellular complexity in ADPKD, identifying novel transcriptomic and epigenomic features in cystic kidney cells.

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

This study integrates snATAC-seq and snRNA-seq data to redefine cellular heterogeneity in the adult human kidney by identifying functional differences in chromatin accessibility and gene expression.

Alcohol causes lasting differential transcription in Drosophila mushroom body neurons

The paper investigates how alcohol affects transcription and RNA processing in Drosophila mushroom body neurons, identifying lasting transcript changes associated with ethanol exposure.

The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

This study uses snRNAseq to analyze early diabetic nephropathy in human kidneys, identifying gene expression changes in potassium secretion and angiogenic signaling across multiple cell types.