Author

Amish Asthana

Wake Forest University Health SciencesORCID 0000-0002-4597-5982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:organoid / primary culture· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Giuseppe OrlandoiD· 2 shared Alexei V MikhailoviD· 1 shared Alice A. TomeiiD· 1 shared Arunkumar RengarajiD· 1 shared Benjamin D. HumphreysiD· 1 shared Christopher A. FrakeriD· 1 shared Emma Peveri· 1 shared Emmanuel C. OparaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPharmacology & Toxicology

Giuseppe OrlandoORCID

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3 papers

Recent·Most cited

Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy

Wonwoo Jeong, Quentin Perrier, Arunkumar Rengaraj, Lori Nicole Byers, Grisell C. Gonzalez, Emma Peveri, Jake Miller, Rita Bottino, Alexei V Mikhailov, Christopher A. Fraker, Emmanuel C. Opara, Alice A. Tomei, Sang Jin Lee, Giuseppe Orlando, Amish Asthana

This paper develops a 3D bioprinting method using decellularized extracellular matrix-enriched bioinks to create functional human islet constructs for beta-cell replacement therapy in type 1 diabetes.

Acta Biomaterialia · Aug 8, 2026Peer-reviewedBioengineering

Dose Modeling for Mitochondrial Transplantation in Barrier-Limited Tissues

Melanie Walker, Giuseppe Orlando, Amish Asthana, Gabriel C. Oniscu, Michael R. Levitt

The paper develops a computational model to estimate mitochondrial transplantation doses for barrier-limited tissues, finding route-adjusted requirements differ from cardiac estimates.

bioRxiv · Jul 8, 2025 · PreprintPharmacology & Toxicology

Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing

Nicolas Ledru, Parker C. Wilson, Yoshiharu Muto, Yasuhiro Yoshimura, Hao Wu, Amish Asthana, Stefan G. Tullius, Sushrut S. Waikar, Giuseppe Orlando, Benjamin D. Humphreys

The paper develops RENIN, a regularized regression method, to predict gene regulatory networks from single nucleus multiomic data and applies it to identify regulators of failed kidney injury response.

bioRxiv · Dec 29, 2022 · PreprintGenomics

Amish Asthana · henhao