ImmunologyGlycobiologyPeer-reviewed
Impact of Glycan Depletion, Glycan Debranching and Increased Glycan Charge on HIV-1 Neutralization Sensitivity and Immunogenicity
Alessio D’Addabbo, Tommy Tong, Emma T Crooks…·James Μ. Binley
This study evaluates glycoengineered HIV-1 trimers to enhance bNAb recognition, finding that B4GalT1+ST6GalT1 modifications increase antibody titers in infected donors but reduce vaccine-induced neutralizing antibodies.
3 citations