Zhongge Zhang

Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria

This study quantifies how gene regulation in E. coli connects DNA to RNA and proteins under growth condition changes, revealing two principles governing protein allocation.

Cellular perception of growth rate and the mechanistic origin of bacterial growth laws

The paper shows that ppGpp in E. coli inversely responds to translational elongation rate, enabling growth rate perception and control through a regulatory circuit.

A systems approach discovers the role and characteristics of seven LysR type transcription factors in Escherichia coli

The paper identifies the functions of seven LysR-type transcription factors in E. coli using multi-omics methods, revealing their roles in nitrogen source utilization and amino acid metabolism.