Christina Ludwig

This study identifies PP2A phosphatase as a potential dephosphorylating enzyme for TRAPPII subunit TRS120 in Arabidopsis, linking kinase-phosphatase balance to membrane trafficking.

This study shows brassinosteroids repress plant immunity by inducing DNA methylation and altering splicing of immune receptor genes through bHLH transcription factors.

This study shows that endogenous RALF peptides, perceived by FER and LLG-LRX complexes, are required for powdery mildew colonization of Arabidopsis, with RALF function influencing cell wall remodeling and apoplastic pH.

This study investigates how titration of an active DnaA variant controls DNA replication in E. coli under different growth conditions, revealing limits and design principles for synthetic replication systems.

The paper identifies sequence adaptations in the intracellular domain of SymRK that enable infection thread progression in root nodule primordia by interacting with SINA E3 ubiquitin ligases.

This study uses proteogenomics to show that transposable elements in Blumeria hordei generate novel transcripts and proteins.

The paper shows that E. faecalis evolves to metabolize fructoselysine, reducing S. Typhimurium colonization by limiting a key nutrient.

The paper identifies a novel gene cluster in Bifidobacterium pseudolongum that enables resistant starch utilization, linking CAZyme profiles to niche adaptation in infant and adult microbiomes.

The paper investigates how microbial communities adapt metabolically in different environments, showing changes in carbon usage, biosynthesis, and interactions across monocultures, in vitro communities, and the mouse gut.

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

This study investigates DnaA titration on the E. coli chromosome and shows it controls free DnaA levels in a growth rate-dependent manner, preventing re-initiation during slow growth.

The paper uses chemical proteomics to analyze KRAS inhibitor effects on signaling networks in cancer cells, revealing cell-specific responses and phosphorylation changes.

The paper engineers Parageobacillus thermoglucosidasius to use methanol via the RuMP cycle for growth, achieving 17% biomass from methanol without heterologous enzyme expression.

The paper identifies CEPR2 as the receptor for group II CEPs, showing its role in cell surface immunity against bacterial infection in Arabidopsis.

This study shows that butyrate is metabolized into the TCA cycle in fly heads and increases oxygen consumption without affecting proteome or acetylome.

The paper shows that CemR regulates metabolic pathways in Campylobacteria to adapt to oxygen availability, impacting ATP production and growth.

This study identifies HP1021 as a regulator of oxidative stress response and competence in H. pylori through multi-omics analysis.

This study quantifies how gene regulation in E. coli connects DNA to RNA and proteins under growth condition changes, revealing two principles governing protein allocation.

The paper identifies and functionally characterizes a novel overlapping gene azyx-1 in C. elegans, showing its role in regulating zyx-1 proteoforms and affecting muscular integrity and locomotion.

This study quantifies the proteome of Clostridium autoethanogenum under different gas conditions, revealing proteome allocation priorities and enzyme dynamics.

Adding tandem mass tag proteomics to genome and transcriptome data resolved 22% of 121 unsolved suspected mitochondrial disease cases and surfaced two new disease genes.