Author

Rudo Kieft

University of GeorgiaORCID 0000-0002-6494-1884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Haidong YaniD· 2 shared Robert J. SchmitziD· 2 shared Robert S. SabatiniiD· 2 shared Laura J. Cliffe· 1 shared Robert Sabatini· 1 shared Stephen L. Hajduk· 1 shared Yang ZhangiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersMolecular Biology

Haidong YanORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 27, 2024

Epigenetic regulation of TERRA transcription, R-loop formation, telomere integrity and metacyclogenesis by base J in Leishmania major.

Rudo Kieft, Robert Sabatini

This study shows that base J regulates TERRA transcription, R-loop formation, telomere integrity, and metacyclogenesis in Leishmania major by controlling Pol II readthrough transcription.

DOI 10.1101/2024.06.27.601056

experimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJun 21, 2024

Mono-allelic epigenetic regulation of bi-directional silencing of RNA Polymerase II polycistronic transcription initiation in Trypanosoma brucei.

Rudo Kieft, Laura J. Cliffe, Haidong Yan…·Robert S. Sabatini

The paper shows that epigenetic mechanisms, including base J modification, regulate mono-allelic transcriptional silencing of adjacent polycistronic gene clusters in Trypanosoma brucei.

DOI 10.1101/2024.06.21.600114

bulk RNA-seqChIP-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 21, 2023

Protein Phosphatase PP1 Regulation of Pol II Phosphorylation is Linked to Transcription Termination and Allelic Exclusion of VSG Genes and TERRA in Trypanosomes.

Rudo Kieft, Yang Zhang, Haidong Yan…·Robert S. Sabatini

This study shows that PP1-1 modulates Pol II termination in T. brucei by dephosphorylating the Pol II large subunit, leading to readthrough transcription and pervasive genome transcription.

3 citations

experimental assay

𝕏 PostBluesky