Long-term Nrf2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy
Lucía Viqueira, Elisa Navarro, Pilar Negredo, Juan Antonio Bernal, Marı́a Isabel Rodrı́guez-Franco, Elena Tortosa, Manuela García López
This study shows that combining Nrf2 activation with microglial repopulation after PLX5622 treatment improves cognitive deficits, neuronal loss, and mitochondrial function in a tauopathy model.
Brain Behavior and Immunity · Jan 4, 2026Peer-reviewedNeuroscience