Juan Antonio Bernal

Long-term Nrf2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy

This study shows that combining Nrf2 activation with microglial repopulation after PLX5622 treatment improves cognitive deficits, neuronal loss, and mitochondrial function in a tauopathy model.

A comprehensive genetic catalog of human double-strand break repair

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome

This paper shows that a mutation breaking the Cys122-to-Cys154 disulfide bond in Kir2.1 channels disrupts PIP2 binding and causes arrhythmias in Andersen-Tawil Syndrome.

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

SARS-CoV-2 protein Nsp1 alters actomyosin cytoskeleton and phenocopies arrhythmogenic cardiomyopathy-related PKP2 mutant

The paper shows that SARS-CoV-2 Nsp1 protein mimics the effects of a PKP2 mutant by altering actomyosin cytoskeleton organization, suggesting a potential link between viral infection and ACM-like disease.