Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein MDM2
Jingjing Liu, Xianlin Zou, Tetsuya Gotoh, Anne M. Brown, Liang Jiang, Esther L. Wisdom, Jae Kyoung Kim, Carla V. Finkielstein
This study identifies MDM2 as a regulator of PER2 degradation and shows it influences circadian rhythm period length through a phosphorylation-independent mechanism.
Science Signaling · Nov 13, 2018Peer-reviewedMolecular Biology