Anne M. Brown

This paper extends the SILCS method with the Drude polarizable force field to improve ligand-nucleic acid interaction modeling and drug design.

This study develops semisynthetic blasticidin S analogs with higher anti-malarial potency and selectivity than the natural product.

This study identifies diverse tetrodotoxin analogs in Pacific newts and shows some are more effective against resistant garter snake sodium channels.

This study identifies a biofilm matrix protein, BsaC, secreted by Clostridium perfringens via type IV pili, and shows BsaA forms intermolecular isopeptide bonds to enhance biofilm fiber strength.

The paper introduces a co-design paradigm to enhance binding affinity between Ndh2 and quinones, demonstrating its application in improving biosensing capabilities.

This study uses MD simulations to investigate the structural mechanisms of S1P transport by Spns2, identifying key residues and a rocker-switch model for potential inhibitor development.

The paper identifies novel Polinton-like viruses associated with entomopoxviruses, revealing their role as hyperparasites and proposing a mechanism for their genomic evolution.

This study identifies MDM2 as a regulator of PER2 degradation and shows it influences circadian rhythm period length through a phosphorylation-independent mechanism.