Charles F. Mactutus

NLRP3 inflammasome-related microglial pyroptosis in EcoHIV infected mice

This study investigates the role of NLRP3 inflammasome and microglial pyroptosis in EcoHIV-infected mice, showing increased NLRP3 and GSDMD expression and reduced markers with MCC950 treatment.

IMPAIRED BRIDGING OF TEMPORAL DISCONTINUITIES IN OLDER ADULT HIV-1 TG RATS

This study evaluates the HIV-1 transgenic rat model for age-related neurocognitive impairments, finding significant deficits linked to neuronal dysfunction and amyloid beta accumulation.

A HISTORY OF ADOLESCENT OXYCODONE SELF-ADMINISTRATION: NEURAL MECHANISMS UNDERLYING NEUROCOGNITIVE IMPAIRMENTS

This study investigates how adolescent oxycodone self-administration affects neurocognitive development by examining sex-dependent changes in dendritic spine morphology and glutamatergic signaling in the anterior cingulate cortex.

S-Equol: A Novel Therapeutic For HIV-1-Associated Gastrointestinal Dysbiosis

This study investigates S-Equol's effect on cocaine-maintained responding in HIV-1 Tg rats, finding microbiome alterations and genotype-specific interactions.

SEX-DEPENDENT MODULATION OF BEHAVIORAL ALLOCATION VIA VENTRAL TEGMENTAL AREA-NUCLEUS ACCUMBENS SHELL CIRCUITRY

This study uses chemogenetics to show that activation of the VTA-AcbSh circuit induces sex-dependent changes in reward-seeking behavior in rodents.

SARS-CoV-2 RNA Persists in the Central Nervous System of Non-Human Primates Despite Clinical Recovery

This study shows SARS-CoV-2 RNA persists in the CNS of recovered non-human primates, with ACE2 and TMPRSS2 downregulation and pericyte infection linked to PASC.

Microglia Proliferation Underlies Synaptic Dysfunction in the Prefrontal Cortex: Implications for the Pathogenesis of HIV-1-Associated Neurocognitive and Affective Alterations

This study investigates microglia proliferation in HIV-1 infection and its link to synaptic dysfunction in the prefrontal cortex, finding that microglia proliferation accounts for significant variance in synaptic dysfunction.

Disrupted Decision-Making: EcoHIV Inoculation Following a History of Cocaine Use

This study shows that EcoHIV inoculation disrupts decision-making in rats with a history of cocaine use, indicating frontal-striatal circuit dysfunction.

Neurodevelopmental processes in the prefrontal cortex derailed by chronic HIV-1 viral protein exposure

This study investigates how chronic exposure to HIV-1 viral proteins disrupts neurodevelopmental processes in the prefrontal cortex of rats, leading to synaptic and dendritic abnormalities.

SYNAPTIC DYSFUNCTION UNDERLIES ALTERATIONS IN THE INITIATION OF GOAL-DIRECTED BEHAVIORS: IMPLICATIONS FOR HIV-1 ASSOCIATED APATHY

This study examines HIV-1 associated apathy in rats by analyzing goal-directed behaviors and synaptic dysfunction in the nucleus accumbens.

Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage

This study shows chronic SSRI treatment can reverse HIV-1 protein-induced synaptodendritic damage in HIV-1 transgenic rats, though neurochemical effects were inconsistent.

HIV-1-induced apathy: Mitigation by the gut metabolite, S-equol

This study evaluates the effects of S-equol on apathy and drug-seeking behavior in HIV-1 transgenic rats, finding it mitigates these issues.

HIV-1 and microglia: EcoHIV and HIV-1 transgenic rats

This study investigates HIV-1 persistence in the brain using HIV-1 transgenic rats and a novel EcoHIV model, showing microglia as the primary cell type expressing HIV-1 mRNA and linking infection to neurocognitive impairments.