This study shows that adolescent alcohol exposure alters perineuronal net (PNN) expression in the infralimbic cortex, reducing the effectiveness of PNN digestion to enhance fear extinction.

Alcohol · Mar 1, 2025Peer-reviewedNeuroscience

Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking

Adam R. Denton, Rachel E. Clarke, Lisa M. Green, Jayda Carroll-Deaton, Annaka M. Westphal, Benjamin M. Siemsen, Ashley G. Brock, Elizabeth A. Hochberg, Jacob Lavine, Makoto Taniguchi, Jacqueline F. McGinty, Alexander C.W. Smith, Constanza García‐Keller, James M. Otis, Michael D. Scofield

This paper identifies nitrergic interneurons as key mediators of cue-induced synaptic plasticity in D1 MSNs required for cocaine seeking, showing that targeting nNOS or mGluR5 blocks relapse.

bioRxiv · Apr 5, 2024 · PreprintNeuroscience

Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage

Adam R. Denton, Charles F. Mactutus, Almeera U. Lateef, Steven B. Harrod, Rosemarie M. Booze

This study shows chronic SSRI treatment can reverse HIV-1 protein-induced synaptodendritic damage in HIV-1 transgenic rats, though neurochemical effects were inconsistent.

Journal of NeuroVirology · May 18, 2021Peer-reviewedNeuroscience