A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces
Max L. Jordan, Hongrui Wang, Natalia M. Vior, Matthew J. Bush, Govind Chandra, Kathryn J. Stratton, Abbas Maqbool, Andrew W. Truman, Susan Schlimpert
This study identifies a conserved NLR activation switch in bacterial AfsR that regulates antibiotic biosynthesis and reveals its evolutionary conservation across Actinomycetota.
bioRxiv · Oct 9, 2026 · PreprintMicrobiology