Govind Chandra

A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces

This study identifies a conserved NLR activation switch in bacterial AfsR that regulates antibiotic biosynthesis and reveals its evolutionary conservation across Actinomycetota.

TrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids

This paper shows TrbA interacts with KorB to lock it as a transcriptional repressor on multi-drug resistance plasmids, using a conserved aromatic interface.

Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota

This paper analyzes the evolution and functional diversification of the WhiG sigma factor in Actinomycetota, revealing two distinct clades with different regulatory mechanisms and expanded biological roles.

Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems

The paper investigates dual ParABS partition systems in Streptomyces plasmid SCP1, showing that while both systems are functional, only parABS1 is essential for plasmid maintenance.

Defining the OrrA regulon and its role in development and antibiotic production in Streptomyces venezuelae NRRL B-65442

This study defines the OrrA regulon in Streptomyces venezuelae, showing it regulates sporulation and antibiotic production via WblA.

A Novel Stress Response Pathway Mediates Antibiotic Tolerance and Architecture in Pseudomonas aeruginosa Biofilms

This study identifies BatR as a regulator of biofilm formation and antibiotic tolerance in Pseudomonas aeruginosa, showing its interaction with SrkA and role in eDNA release and pyocyanin production.

Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

This study identifies CisA as a membrane protein essential for the function of the Streptomyces coelicolor contractile injection system, showing it mediates recruitment to the membrane and firing.

Assembly of a segrosome by a CTP-independent ParB-like protein

This study identifies a CTP-independent ParABS system in Streptomyces coelicolor that segregates plasmid SCP2 through a ParT protein that diffuses on DNA without CTP binding or hydrolysis.

The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces species

This paper identifies CutRS as a two-component system in Streptomyces that senses secretion stress via cysteine residues and regulates antibiotic production in response to glucose.