Author

Andrew W. Truman

John Innes CentreORCID 0000-0001-5453-7485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:bacteria (other)· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

Javier Santos‐AberturasiD· 3 shared Abbas MaqbooliD· 1 shared Alaster D. MoffatiD· 1 shared Anna Rita CappelloiD· 1 shared Anne OsbourniD· 1 shared Aphidech SangdeeiD· 1 shared Carolina GrandellisiD· 1 shared Danny VereeckeiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Javier Santos‐AberturasORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 9, 2026

A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces

Max L. Jordan, Hongrui Wang, Natalia M. Vior…·Susan Schlimpert

This study identifies a conserved NLR activation switch in bacterial AfsR that regulates antibiotic biosynthesis and reveals its evolutionary conservation across Actinomycetota.

DOI 10.64898/2026.09.02.748808

bacteria (other)comparative / phylogenetic analysis

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintJan 8, 2026

Efficient in vitro refactoring and biosynthetic gene cluster amplification for the overproduction and accelerated discovery of anticancer thioamitides

Javier Santos‐Aberturas, Luca Frattaruolo, Eleonora Tassinari…·Andrew W. Truman

The paper describes methods to enhance thioalbamide production by refactoring its biosynthetic gene cluster and identifies a related compound with anticancer activity.

DOI 10.64898/2026.01.07.698260

bacteria (other)experimental assay

𝕏 PostBluesky

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedMay 19, 2025

Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen Rhodococcus fascians guides structural revision and identification of molecular target

Jonathan J. Ford, Javier Santos‐Aberturas, Edward S. Hems…·Andrew W. Truman

The paper identifies a biosynthetic gene cluster in Rhodococcus fascians that produces lydiamycin A, a novel HPS-containing macrocyclic pentapeptide with antibacterial activity against peptide deformylase.

10 citationstop 4%

bacteria (other)metagenomics

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedAug 29, 2024

Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone in Pseudomonas spp.

Alaster D. Moffat, Lars Höing, Javier Santos‐Aberturas…·Andrew W. Truman

This study identifies 3,7-dihydroxytropolone as a new antimicrobial compound produced by Pseudomonas, revealing its biosynthesis pathway and ecological relevance.

10 citations

bacteria (other)metabolomics

𝕏 PostBluesky