This study identifies a regulatory axis involving TGF-beta2, OPTN, FOXC1, and miR-200 that modulates intraocular pressure by affecting extracellular matrix and circadian rhythms in trabecular meshwork cells.

BBA Advances · Dec 2, 2025Peer-reviewedCell Biology

Characterization, enrichment, and computational modeling of cross-linked actin networks in trabecular meshwork cells

Haiyan Li, Devon Hori Harvey, Jiannong Dai, Steven P. Swingle, Anthony Malik Compton, Chenna Kesavulu Sugali, Kamesh Dhamodaran, Jing Yao, Tsai-Yu Lin, Todd Sulchek, Taeyoon Kim, C. Ross Ethier, Weiming Mao

The paper enhances CLAN incidence in GTM3L cells through sorting and substrate stiffness manipulation and models their biomechanical impact on cell stiffness and nuclear resistance.

Investigative Ophthalmology & Visual Science · Feb 26, 2025Peer-reviewedCell Biology

Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor

Jiannong Dai, Naga Pradeep Rayana, Michael Peng, Chenna Kesavulu Sugali, Devon Hori Harvey, Kamesh Dhamodaran, Eric Yu, Joseph Martin Dalloul, Shaohui Liu, Weiming Mao

This study investigates the effect of a Rho kinase inhibitor on pterygium cell fibrosis, finding it reduces cell viability, migration, and extracellular matrix markers.

Scientific Reports · Dec 28, 2024Peer-reviewedPharmacology & Toxicology