Taeyoon Kim

Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo

This study uses advanced microscopy to show that myosin II minifilaments persist and recycle in C. elegans embryos, contributing to cortical contractility through stable, static interactions with actin.

Mechanical Checkpoint for Cell Division in Three-Dimensional Microenvironments

The paper identifies three modes of ECM resistance during cell division in 3D microenvironments and highlights the dominance of pericellular shear resistance.

Durotactic Migration Driven by Anisotropic Matrix Stiffening and Mechanical Feedback

The paper develops a biomechanical model to study how cells remodel fibrous matrices to drive durotactic migration, showing collective behavior similar to cancer metastasis.

Kinetic Control of Out-Of-Equilibrium Dynamics in the RhoA Signaling Cascade Shapes Actomyosin Contractility

The paper investigates the kinetic delays in the RhoA signaling cascade during actomyosin contractility in C. elegans embryos and shows they actively control force deployment.

The Mechanism of Dynamic Steady States in Lamellipodia

This study uses an agent-based model to show how physical interactions in lamellipodia create and maintain a dynamic steady state with retrograde flow.

Computational Modeling of Motor-Driven Extension of Microtubule Bundles in Axons

This study uses a computational model to show that intermediate cross-linking density and microtubule stiffness maximize axonal outgrowth by balancing buckling resistance and mechanical load.

Impacts of Structural Properties of Myosin II Filaments on Force Generation

This study uses an agent-based model to show how structural properties of myosin II filaments affect force generation in actomyosin structures.

Agent-based computational modeling of the stochastic dynamic behavior of actin filaments recapitulates the homeostatic cortical array in plant epidermal cells

The paper develops an agent-based model to simulate stochastic actin filament dynamics in plant epidermal cells, reproducing experimental observations of filament abundance, length, and dynamic events.

Dissecting Molecular Origins of the Mechano-Adaptive Behaviors of Actomyosin Bundles

This study investigates how actomyosin bundles adapt to mechanical stress through experiments and simulations, revealing rate-dependent behaviors and key factors influencing their response.

Reconstitution of actomyosin networks in cell-sized liposomes reveals distinct mechanical roles of cytoskeletal organization in membrane shape remodeling

This study uses reconstituted actomyosin networks in liposomes to show how actin network connectivity and coupling strength control membrane deformation and bleb formation mechanisms.

Cluster Formation and Phase Separation Driven by Mobile Myosin Motors in the Motility Assay

This study simulates the motility assay with mobile myosin motors and shows that F-actin clusters form with polar ordering and phase separation, dependent on actin length and concentration.

Characterization, enrichment, and computational modeling of cross-linked actin networks in trabecular meshwork cells

The paper enhances CLAN incidence in GTM3L cells through sorting and substrate stiffness manipulation and models their biomechanical impact on cell stiffness and nuclear resistance.

Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion

This study shows that swirling motion of breast cancer cells aligns collagen fibers radially, enabling collective invasion by generating contractile stresses.

Fine-Tuning of Material Properties via Catch Bonds

This study uses an agent-based model to show that catch-slip bonds enhance the mechanical properties of polymer networks and aid myosin motors in generating contractile forces.