Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1
Johannes F. Van Agthoven, Hengameh Shams, Frank V. Cochran, José L. Alonso, James R. Kintzing, Kiavash Garakani, Brian D. Adair, Jian-Ping Xiong, Mohammad R. K. Mofrad, Jennifer R. Cochran, M. Amin Arnaout
The paper determines the structures of engineered knottins 2.5F and 2.5D in complex with integrin αVβ3 and reveals structural mechanisms underlying their differential binding to αVβ3 and α5β1.
Structure · Jul 25, 2019Peer-reviewedMolecular Biology