Author

Brian D. Adair

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Jian-Ping XiongiD· 2 shared Johannes F. Van AgthoveniD· 2 shared José L. Alonso· 2 shared M. Amin ArnaoutiD· 2 shared Clary B. ClishiD· 1 shared Conroy O. FieldiD· 1 shared David A. TessiD· 1 shared Donald W. LandryiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersPathology

Jian-Ping XiongORCID

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2 papers

Recent·Most cited

Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model

Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi‐Xian Deng, Hyun-Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes F. Van Agthoven, Mark J. Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout

This paper shows that m-tirofiban, a non-partial agonist of IIbβ3, effectively inhibits venous thrombosis without increasing bleeding in a mouse model.

Nature Communications · Oct 4, 2024Peer-reviewedPathology

Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1

Johannes F. Van Agthoven, Hengameh Shams, Frank V. Cochran, José L. Alonso, James R. Kintzing, Kiavash Garakani, Brian D. Adair, Jian-Ping Xiong, Mohammad R. K. Mofrad, Jennifer R. Cochran, M. Amin Arnaout

The paper determines the structures of engineered knottins 2.5F and 2.5D in complex with integrin αVβ3 and reveals structural mechanisms underlying their differential binding to αVβ3 and α5β1.

Structure · Jul 25, 2019Peer-reviewedMolecular Biology