Evolutionary rescue of spherical mreB deletion mutants of the rod-shape bacterium Pseudomonas fluorescens SBW25
P Richard J Yulo, Nicolas Desprat, Monica L. Gerth, Barbara Ritzl-Rinkenberger, Andrew D. Farr, Yunhao Liu, Xuexian Zhang, Michael Miller, Felipe Cava, Paul B. Rainey, Heather Lyn Hendrickson
This study shows that spherical mreB deletion mutants of Pseudomonas fluorescens SBW25 can regain fitness through mutations in Pbp1A, restoring cell size homeostasis and supporting a hypothesis about balanced transpeptidase and glycosyltransferase functions.
bioRxiv · Dec 17, 2024Microbiology