BioengineeringCell chemical biologyPeer-reviewed
Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency
Wei‐Yao Wang, Mehman I. Bunyatov, Deana Moffat…·Matthew P. DeLisa
This study enhances the affinity and cytotoxicity of an anti-polysialic acid antibody through rational design and directed evolution, resulting in more potent variants.