Author

De‐Sheng Ker

University of CambridgeORCID 0000-0002-6564-4056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Luca PellegriniiD· 2 shared Hedaya AboalnagaiD· 1 shared Mairi Louise KilkennyiD· 1 shared Zhan YiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBiochemistry

Luca PellegriniORCID

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2 papers

Recent·Most cited

BiochemistryBioscience ReportsPeer-reviewedSep 24, 2026

High-resolution cryoEM of nucleosomes in nuclear extracts of mammalian cells

De‐Sheng Ker, Hedaya Aboalnaga, Luca Pellegrini

The paper presents a method for high-resolution cryoEM of nucleosomes in mammalian cell nuclear extracts without requiring thin sectioning.

DOI 10.1042/bsr20260477

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Molecular BiologyFEBS JournalPeer-reviewedFeb 9, 2024

CryoEM insights into RNA primer synthesis by the human primosome

Zhan Yin, Mairi Louise Kilkenny, De‐Sheng Ker, Luca Pellegrini

This study uses cryoEM to capture the conformational changes of the human primosome during RNA primer synthesis, revealing how primase and polymerase subunits coordinate primer synthesis and termination.

8 citations

humanexperimental assay

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