Author

Danielle M. Heller

Howard Hughes Medical InstituteORCID 0000-0002-6581-1256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:bacteria (other)· 1

Frequent Co-Authors

Alyssa Lee· 2 shared Arturo DiaziD· 2 shared Cole R. JirsaiD· 2 shared A. K. NayakiD· 1 shared Abigail Brooks· 1 shared Alexandra Falvo· 1 shared Amara Lovings· 1 shared Amina Adebiyi· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

Alyssa Lee

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Identification of novel inhibitors of Mycobacterium smegmatis growth through genome-wide overexpression of Cluster P3 mycobacteriophage Xavia genes

Anushka Tennakoon, Iresha Edirisingha, Cole R. Jirsa, Ethan Rutledge, Ankita Bhattacharyya, Ella King, Madelyn Moresi, Amara Lovings, Parker Richard Yarborough, Anna Hoben, Garrett Manns, Toney Ray Gibson, Syed Mohammed Ashfaque Uddin, Yeseul Bae, Natalie Taylor, , Ramesh Rijal

The paper screens mycobacteriophage Xavia genes for growth inhibition of Mycobacterium smegmatis and identifies toxic and growth-reducing genes.

G3 Genes Genomes Genetics · Sep 16, 2026Peer-reviewedMicrobiology

Identification and characterization of host-modulating effectors encoded by the Cluster F1 mycobacteriophage NormanBulbieJr

Bethany M. Wise, Kaylia Edwards, Cole R. Jirsa, Sabrina Abbruzzese, Amina Adebiyi, Sarika Bapat, Tyler Barnhardt, Naomi Bastiampillai, Ella Begovic, Mary Grace Berchick, Gilda Bocco, John Bonoris, Elizabeth Boos, Margaret Cassady, Julia C. Chehab, , Danielle M. Heller

This study identifies and characterizes 29 host-modulating effectors from the mycobacteriophage NBJ that inhibit mycobacterial growth and contribute to phage defense mechanisms.

bioRxiv · May 4, 2026 · PreprintMicrobiology

Functional Characterization of 123 Genes from Mycobacteriophage LeBron Uncovers Cytotoxic Gene Families in Cluster L1

Earick J Cagang, Brian Nguyen, Elizabeth Paul, Elva Garcia, Alyssa Lee, Sabrina Benitez, Rita Dementyev, Ethan Dewri, Alexandra Falvo, Christian Figueroa, Dulce Guevara, Katie Jang, Michael Kelly, Caleb Kim, Soojeong Moon, , Arturo Diaz

This study functionally characterizes 123 genes from mycobacteriophage LeBron, identifying 39 cytotoxic genes, including novel families, and highlights functional conservation across phage clusters.

bioRxiv · Dec 17, 2025 · PreprintMicrobiology

Genome-wide screen overexpressing mycobacteriophage Amelie genes identifies multiple inhibitors of mycobacterial growth

Chelsea Tafoya, Brandon Ching, E. P. Garcia, Alyssa Lee, Melissa Acevedo, Kelsey Bass, Elizabeth Chau, Heidi Lin, Kaitlyn Mamora, Michael Reeves, Madyllyne Vaca, William van Iderstein, Luis Velasco, Vivianna Williams, Grant Yonemoto, , Arturo Diaz

This study overexpresses 76 genes from mycobacteriophage Amelie and identifies 26 genes that inhibit Mycobacterium smegmatis growth, including eight previously unknown cytotoxic gene families.

G3 Genes Genomes Genetics · Dec 5, 2024Peer-reviewedMicrobiology