Author

Alessandra Castaldi

University of California San DiegoORCID 0000-0002-6616-6519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Beiyun ZhouiD· 2 shared Crystal N. MarconettiD· 2 shared Zea BorokiD· 2 shared A. Allen· 1 shared Allen WangiD· 1 shared Amy L. RyaniD· 1 shared Ana Kasirer‐FriedeiD· 1 shared Angela MeieriD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Beiyun ZhouORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 1, 2025

Loss of tight junction protein claudin 18 uncovers alveolar epithelial stem cell plasticity and emergence of non-fibrogenic transitional progenitors

Alessandra Castaldi, J. Chin, B Ma…·Zea Borok

The paper identifies regeneration-associated transitional progenitors (RATPs) in Cldn18 knockout mice, showing they are less fibrogenic and contribute to lung repair rather than fibrosis.

DOI 10.1101/2025.10.01.679859

mousebulk RNA-seq

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BioinformaticsbioRxivPreprintApr 5, 2024

Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis

Laurence St. Pierre, Asres Berhan, Eun Kyu Sung…·Zea Borok

The paper identifies TRIP13 as a mediator of AT2 cell dysfunction in IPF through integrated transcriptomic and epigenomic analysis and shows TRIP13 inhibition prevents mesenchymal gene signature acquisition.

DOI 10.1101/2024.04.05.588292

humanbulk RNA-seq

𝕏 PostBluesky