Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
Laurence St. Pierre, Asres Berhan, Eun Kyu Sung, Juan R. Alvarez, Hongjun Wang, Yanbin Ji, Yixin Liu, Haoze Vincent Yu, Angela Meier, Kamyar Afshar, Eugene M. Golts, Grace Lin, Alessandra Castaldi, Ben A. Calvert, Amy L. Ryan, , Zea Borok
The paper identifies TRIP13 as a mediator of AT2 cell dysfunction in IPF through integrated transcriptomic and epigenomic analysis and shows TRIP13 inhibition prevents mesenchymal gene signature acquisition.
bioRxiv · Apr 5, 2024 · PreprintBioinformatics