Hongyi Zhou

This study compares addictive and non-addictive drugs by analyzing their molecular targets and pathways in brain circuits, revealing distinct engagement patterns linked to addiction propensity.

PHENOCAUZ links symptoms to their molecular causes using Mendelian disease biology, predicting symptom-causing proteins and enabling drug safety and therapeutic target discovery.

GlueFinder identifies molecular glue binding sites near protein interfaces, enabling rational design of degraders that recruit diverse E3 ligases to therapeutic targets.

MENDELSEEK predicts Mendelian genes using machine learning, achieving high accuracy and identifying novel candidates with precision over 0.7.