Bharath Srinivasan

The paper investigates if structural mechanisms of protein pocket engagement can predict drug-drug interactions without clinical data, finding high precision in identifying known interactions.

The paper maps human metabolite-protein interactions using LIGMAP and shows improved pathway coverage and prediction when combined with STRING and BioLiP2.

The paper analyzes protein-ligand interactions to show that ancient metabolites form a globally connected network across protein families, while non-ancient metabolites expand this network without disrupting its connectivity.

The paper analyzes 4,311 protein-small-molecule interactions to show that binding kinetics are mainly controlled by protein dynamics, not ligand structure.

GlueFinder identifies molecular glue binding sites near protein interfaces, enabling rational design of degraders that recruit diverse E3 ligases to therapeutic targets.