GLI transcriptional repression is inert prior to Hedgehog pathway activation
Rachel K. Lex, Weiqiang Zhou, Zhicheng Ji, Kristin N. Falkenstein, Kaleigh E. Schuler, Kathryn E. Windsor, Joseph D. Kim, Hongkai Ji, Steven A. Vokes
The paper shows GLI3 repression does not prevent precocious activation of HH target genes or regulate anterior-posterior limb polarity.
Nature Communications · Feb 10, 2022Peer-reviewedDevelopmental Biology