Author

Rachel K. Lex

Fred Hutch Cancer CenterORCID 0000-0002-1643-5610Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Hongkai JiiD· 3 shared Steven A. VokesiD· 3 shared Weiqiang ZhouiD· 3 shared Kathryn E. Windsor· 2 shared Kristin N. Falkenstein· 2 shared Zhicheng JiiD· 2 shared Anna ElziD· 1 shared Annalyssa Long· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersDevelopmental Biology

Hongkai JiORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 14, 2026

Dysregulation of epithelial differentiation architecture underlies field cancerization in head and neck cancer

Claire Mills, Yin Huang, Chan Mi Lee…·Slobodan Beronja

This study identifies molecular and architectural changes in normal-adjacent field tissue in HNSCC that disrupt epithelial differentiation and may promote cancer development.

DOI 10.64898/2026.10.12.757511

humanwhole-genome sequencing

𝕏 PostBluesky

Developmental BiologyDevelopmental BiologyPeer-reviewedOct 5, 2023

BAF chromatin complexes do not mediate GLI transcriptional repression of Hedgehog target genes

Janani Ramachandran, Wanlu Chen, Rachel K. Lex…·Steven A. Vokes

The paper shows SMARCC1 does not mediate GLI3 repression of Hedgehog target genes, as it maintains chromatin accessibility at GLI-regulated enhancers independently of GLI3.

DOI 10.1016/j.ydbio.2023.10.001

mousebulk RNA-seq

𝕏 PostBluesky

Developmental BiologyNature CommunicationsPeer-reviewedFeb 10, 2022

GLI transcriptional repression is inert prior to Hedgehog pathway activation

Rachel K. Lex, Weiqiang Zhou, Zhicheng Ji…·Steven A. Vokes

The paper shows GLI3 repression does not prevent precocious activation of HH target genes or regulate anterior-posterior limb polarity.

30 citations

mouseexperimental assay

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Developmental BiologyeLifePeer-reviewedJan 27, 2020

GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

Rachel K. Lex, Zhicheng Ji, Kristin N. Falkenstein…·Steven A. Vokes

The paper identifies HH-responsive enhancers that lose acetylation in the absence of Hedgehog signaling and are regulated by GLI repression rather than Polycomb complexes.

32 citations

mouseChIP-seq

𝕏 PostBluesky