Steven A. Vokes

Developmental and transcriptional programs that define the initiation of the forelimb

The paper identifies four stages of forelimb initiation in mouse embryos using scRNA-seq and other sequencing methods, revealing TBX5-target genes involved in limb development.

BAF chromatin complexes do not mediate GLI transcriptional repression of Hedgehog target genes

The paper shows SMARCC1 does not mediate GLI3 repression of Hedgehog target genes, as it maintains chromatin accessibility at GLI-regulated enhancers independently of GLI3.

Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

This study shows that Sonic hedgehog (SHH) signaling is critical for maintaining epithelial integrity in the larynx and anterior foregut, with SHH loss causing abnormal epithelial to mesenchymal transition and replacement by Pax-1 expressing cells.

GLI transcriptional repression is inert prior to Hedgehog pathway activation

The paper shows GLI3 repression does not prevent precocious activation of HH target genes or regulate anterior-posterior limb polarity.

GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

The paper identifies HH-responsive enhancers that lose acetylation in the absence of Hedgehog signaling and are regulated by GLI repression rather than Polycomb complexes.

Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis

This study shows PRMT5 regulates terminal hypertrophic chondrocyte differentiation and models infantile idiopathic scoliosis in mice.