Felix Dietlein

This study maps the spatio-temporal DNA methylation patterns in ovarian cancer using longitudinal data from the DECIDER trial, showing early establishment of regulatory methylomes and their stability through treatment.

The paper identifies nine transcriptional programs driving metastasis in ovarian cancer using multi-modal data from 350 tumor samples, highlighting intra-patient heterogeneity and therapeutic implications.

This paper reports a case where platinum chemotherapy exposure was linked to the development of aggressive thyroid cancer through mutational signatures and genomic analysis.

This study identifies novel cancer driver genes by analyzing mutation nucleotide contexts in whole-exome sequencing data from 12,004 tumors.