Engineered ADARs enable single-nucleotide resolution DNA A-to-G editing without bystander effects
Hyeon Woo Im, Bada Jeong, Ye-Ji Lee, Ye Eun Oh, Chanju Jung, Yong-Woo Kim, Heesoo Uhm, Sangsu Bae
This paper introduces snuABE, a single-nucleotide resolution ABE that reduces bystander effects through engineered ADAR and tagRNA design, achieving precise A-to-G editing in human cells.
bioRxiv · Jul 19, 2025 · PreprintBioengineering