Heesoo Uhm

This paper introduces a gene replacement tool called Prime Assembly (PA) that efficiently and accurately replaces large DNA fragments in human cells, restoring gene function in disease-related genes.

The paper uses AI to generate a small MLH1 binder that enhances prime editing efficiency by disrupting MMR, resulting in the highest PE efficiency to date.

This paper introduces snuABE, a single-nucleotide resolution ABE that reduces bystander effects through engineered ADAR and tagRNA design, achieving precise A-to-G editing in human cells.