Chanju Jung

This paper introduces a gene replacement tool called Prime Assembly (PA) that efficiently and accurately replaces large DNA fragments in human cells, restoring gene function in disease-related genes.

This study shows that base editing in human embryos produces efficient on-target changes without chromosomal abnormalities or large deletions, unlike CRISPR/Cas9-induced DSBs.

The paper introduces a nanopore sequencing method with Cas9 targeting and an analysis algorithm to detect STR expansions, identifying pathogenic repeats in cerebellar ataxia patients.

This paper introduces snuABE, a single-nucleotide resolution ABE that reduces bystander effects through engineered ADAR and tagRNA design, achieving precise A-to-G editing in human cells.

The paper introduces CHEETAH, a system using reprogrammed tracrRNAs to capture and record intracellular RNAs in human cells, demonstrating its ability to self-edit, selectively record viral RNA fragments, and enable multiplexed, time-resolved recording.