Loss of PIKfyve drives the spongiform degeneration in prion diseases
Asvin KK Lakkaraju, Karl Frontzek, Emina Lemes, U. Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi
The paper shows that loss of PIKfyve contributes to spongiform degeneration in prion diseases by linking prion infection to PIKfyve destabilization and vacuolation.
EMBO Molecular Medicine · Jul 22, 2021Peer-reviewedNeuroscience