Author

Edwin Mientjes

Erasmus MCORCID 0000-0002-6700-9259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

Ype ElgersmaiD· 2 shared A. Mattijs PuntiD· 1 shared Ben DisteliD· 1 shared Claudia Milazzo· 1 shared F. Isabella ZampetaiD· 1 shared Ilona J. de GraafiD· 1 shared Jeroen DemmersiD· 1 shared Marlene van den Berg· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Ype ElgersmaORCID

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2 papers

Recent·Most cited

UBE3A reinstatement restores behavior and proteome in an Angelman Syndrome mouse model of Imprinting Defects

Claudia Milazzo, Ramanathan Narayanan, Solveig Badillo, Silvia Wang, Rosaisela Almand, Edwin Mientjes, Stormy J. Chamberlain, Thomas Kremer, Ype Elgersma

This study shows that restoring UBE3A expression in a mouse model of Angelman Syndrome improves behavior and proteome, supporting UBE3A reinstatement as a therapeutic strategy.

bioRxiv · Sep 29, 2024 · PreprintNeuroscience

Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function

Rossella Avagliano Trezza, A. Mattijs Punt, Edwin Mientjes, Marlene van den Berg, F. Isabella Zampeta, Ilona J. de Graaf, Yana van der Weegen, Jeroen Demmers, Ype Elgersma, Ben Distel

This study identifies RPH3A as a novel UBE3A ubiquitination target and shows that UBE3A mono-ubiquitination of RPH3A does not mediate degradation.

Scientific Reports · Feb 4, 2021Peer-reviewedNeuroscience