Author

Solveig Badillo

F. Hoffmann-La Roche AGORCID 0000-0002-7563-111XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Thomas Kremer· 2 shared Annamaria Braendli-Baiocco· 1 shared Azad BonniiD· 1 shared Charlotte BoniD· 1 shared Claudia Milazzo· 1 shared Congwei WangiD· 1 shared Danièle Buchy· 1 shared Disa TehleriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Thomas Kremer

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2 papers

Recent·Most cited

UBE3A reinstatement restores behavior and proteome in an Angelman Syndrome mouse model of Imprinting Defects

Claudia Milazzo, Ramanathan Narayanan, Solveig Badillo, Silvia Wang, Rosaisela Almand, Edwin Mientjes, Stormy J. Chamberlain, Thomas Kremer, Ype Elgersma

This study shows that restoring UBE3A expression in a mouse model of Angelman Syndrome improves behavior and proteome, supporting UBE3A reinstatement as a therapeutic strategy.

bioRxiv · Sep 29, 2024 · PreprintNeuroscience

Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey

Ravi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Danièle Buchy, Marco Berrera, Megana K. Prasad, Marco Terrigno, Nikhil Janak Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T. Miller, Kamille Dumong Erichsen, , Marius Christian Hoener

The paper identifies a potent ASO targeting UBE3A-ATS in Angelman syndrome patient neurons, showing long-lasting effects in cynomolgus monkeys.

bioRxiv · Jun 9, 2022 · PreprintNeuroscience